You need to use FFI but you should not need to write any native code for that:
import 'package:ffi/ffi.dart';
final mem = malloc.allocate<Uint8>(n);
final list = mem.asTypedList(n, finalizer: malloc.nativeFree);
// You can sent `mem` to another isolate and there `asTypeList` it.
This is all you need. Just need to be careful with finalization (don’t attach multiple finalizers or you would need more complicated lifetime management scheme with ref counting).